Direct Reprogramming into Desired Cell Types by Defined Factors
نویسندگان
چکیده
منابع مشابه
Direct reprogramming into desired cell types by defined factors.
In the field of developmental biology, the concept that cells, once terminally differentiated, are fixed in their cell fate was long believed to be true. However, Dr. Gurdon and colleagues challenged this fundamental doctrine and demonstrated that cellular reprogramming and cell fate conversion are possible by somatic nuclear transfer and cell fusion. The Weintraub laboratory discovered in the ...
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Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem or progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gata4, Hnf1α, and Foxa3 in p19 Arf null mouse embryonic fibroblasts (MEFs). Here, we show that Hn...
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 2013
ISSN: 0022-9717,1880-1293
DOI: 10.2302/kjm.2012-0017-re